Do creams with “plant stem cells” help to fade scars?

The phenomenon of callus creation from differentiated adult plant cells was described for the first time in 1902 by the Austrian botanist, Gottlieb Haberlandt [5]. He suggested that the individual plant cell is able to regenerate the entire plant. This itself was demonstrated in 1958 by cloning a carrot from in vitro cultivated carrot cells [6]. Since then, many articles have been published dedicated to regeneration of the entire plant from the cultivated cells and/or tissues. The callus creation process is one stage of somatic embryogenesis (i.e., formation of a zygote without fertilization) and the plant cells are subjected to dedifferentiation to again become stem cells capable of producing a new tissue or even an entire organ. The WUS protein is responsible for turning somatic cells back into stem cells. Research shows that cytokines are responsible for the production of stems from a callus, while auxins are responsible for the production of roots [6]. (from Plant stem cells in cosmetics: current trends and future directions, Future Sci OA. 2017 Nov; 3(4): FSO226. doi: 10.4155/fsoa-2017–0026)

In fact, almost all cosmetic companies advertising to contain stem cells in their products actually contain stem cell extracts and not the live stem cells.

IAA is listed in its MSDS as mutagenic to mammalian somatic cells, and possibly carcinogenic based on animal data. It may cause adverse reproductive effects (fetotoxicity) and birth defects based on animal data. No human data as of 2008. It is listed as a potential skin, eye, and respiratory irritant, and users are warned not to ingest it. Protocols for ingestion, inhalation, and skin/eye exposure are standard for moderately poisonous compounds and include thorough rinsing in the case of skin and eyes, fresh air in the case of inhalation, and immediately contacting a physician in all cases to determine the best course of action and not to induce vomiting when of ingested. The NFPA 704 health hazard rating for IAA is 2, which denotes a risk of temporary incapacitation with intense or prolonged, but not chronic exposure, and a possibility of residual injury. [21]

IAA produces microcephaly in rats during the early stage of cerebral cortex development. IAA decreased the locomotor activities of rat embryos/fetuses; treatment with IAA and analog 1(methyl)-IAA resulted in apoptosis of neuroepithelial cell and significantly decreased brain sizes relative to body weight in embryonic rats. [22]



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